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Inbred Strains of Mice: BSVS


Inbr: F 99 +?. Albino. Genet: c. Origin: see BRVR.


Susceptible to Salmonella, some encephalitic viruses and experimental allergic encephalomyelitis (Staats, 1976). Susceptible to St Louis encephalitis and yellow fever virus (Boheme 1970). According to Levine and Sowinski (1973), resistant to experimental allergic encephalomyelitis (cf. 6/14), but 100% susceptible according to Schneider et al. (1957). Sensitive to anaphylaxis after sensitisation with BSA and increased sensitivity to serotonin following pertussis vaccine (Rose et al., 1973., 1973). Susceptible to induction of experimental autoimmune thyroiditis (cf. 3/5) (Vladutiu and Rose, 1971a). Spontaneous congenital hydronephrosis 5% in males, zero in females (Collins et al., 1971., 1971). Extremely sensitive to traumatic shock (Halevy and Altura, 1974). Has a defective immune response to DNP-haemocyanin and streptococcal group A carbohydrate, which are T-cell-dependent (Briles et al., 1976., 1976).

Briles D. E., Krause R. M., and Davie J. M. (1976) Genetic control of non-H-2 linked T-dependent antibody response defects of the BSVS mouse. Fed. Proc. 35, 824. \par

Collins G. R., Goodheart C. R., and Henson D. (1971) Spontaneous heritable hydronephrosis in inbred mice. I. Description, incidence and distribution of lesions. Lab. Animal Sci. 22, 333-338. \par

Halevy S. and Altura B. M. (1974) Genetic factors influencing resistance to trauma. Circulatory Shock 1, 287-293. \par

Levine S. and Sowinski R. (1973) Experimental allergic encephelomyelitis in inbred and outbred mice. J. Immunol. 110, 139-143. \par

Rose N. R., Vladutiu A. O., David C. S., and Shreffier D. C. (1973) Autoimmune murine thyroiditis. V. Genetic influence on the disease in BSVS and BRVR mice. Clin. Exp. Immunol. 15, 281-287. \par

Schneider N. A., Lee J. M., and Olitsky P. K. (1957) Effect of nutrition on the production of acute disseminated encephelomyelitis in mice. J. Exp. Med. 105, 319-334. \par

Staats J. (1976) Standardized nomenclature for inbred strains of mice: Sixth listing. Cancer Res. 36, 4333-4377. \par

Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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