of Mice: BDP
Inbr: F94. Pink-eyed fawn. Genet: a
, b, d, p, rd, se.
by W. H. Gates 1926 from a dilute brown female from Little and a pink-eyed
female from Strong (Staats, 1976
). Inbred since
1926. Maint. by J.
Low food drive (14/15) and high emotionality (2/15) (Thompson,
). Nervous (Staats, 1976
Life-span and spontaneous disease
Short life-span in conventional conditions (4/22 = 421 days in males,
6/22 = 468 days in females) (Storer, 1966
Frequent mammary tumours, polycystic or granular kidneys (Staats,
Normal physiology and biochemistry
High plasma cholesterol at 12 and 24 weeks (3/8) (Weibust,
). Low porphyrin content of Harderian gland (2/16) (Margolis,
). High susceptibility to audiogenic and electroconvulsive seizures
(2/6) (Deckard et al., 1976
High serum complement activity (c.f. 8/26) (Ong
et al 1989
Large kidney/body weight ratio (3/21) (Schlager,
Resistant to X-irradiation (8/27) (Roderick, 1963
Erythrocytes have a high agglutinability (cf. 14/25) (Rubinstein et al., 1974
Murine acquired immune deficiency (MAIDS) is an immunosuppressive disease
of mice induced by infection with the LP-BM5 murine leukemia retrovirus.
Strain BDP has a novel disease phenotype with recovery of immune function
after a period of profound immune suppression. This is inherited as a
dominant character in crosses with both susceptible and resistant strains
B. S., Lieff B., Schlesinger K., and DeFries J. C. (1976) Developmental
patterns of seizure susceptibility in inbred strains of mice. Devel.
Psychobiol. 9, 17.
Gilmore G. L. (1997)
Recovery from retrovirus-induced immune suppression in BDP/J mice: Dominance
of the 'regressor' phenotype. Immunol. 90, 7-13.
Margolis F. L.
(1971) Regulation of porphyrin biosynthesis in the Harderian gland of
inbred mouse strains. Arch. Biochem. Biophys. 145, 373-381.
Ong G. L. and
Mattes M. J. (1989) Mouse strains with typical mammalian levels of complement
activity. J. Immunol. Methods 125, 147-158.
Roderick T. H.
(1963) The response of twenty-seven inbred strains of mice to daily doses
of whole-body X-irradiation. Radiation Res. 20, 631-639.
P., Liu N., Strenn E. W., and Decary F. (1974) Electrophoretic mobility
and agglutinability of red blood cells: a `new' polymorphism in mice.
J. Exp. Med. 139, 313-322.
Schlager G. (1968)
Kidney weight in mice: strain differences and genetic determination. J.
Hered. 59, 171-174.
Staats J. (1976) Standardized
nomenclature for inbred strains of mice: Sixth listing. Cancer Res.
Storer J. B. (1966)
Longevity and gross pathology at death in 22 inbred strains of mice. J.
Gerontol. 21, 404-409.
Thompson W. R.
(1953) The inheritance of behaviour: behavioural differences in fifteen
mouse strains. Can. J. Psychol. 7, 145-155.
Weibust R. S. (1973)
Inheritance of plasma cholesterol levels in mice. Genetics 73,
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,