Inbred Strains
of Mice: BDP
Inbr: F94. Pink-eyed fawn. Genet:
a,
b, d, p, rd, se. Developed
by W. H. Gates 1926 from a dilute brown female from Little and a pink-eyed
female from Strong (
Staats, 1976). Inbred since
1926. Maint. by J.
Behaviour
Low food drive (14/15) and high emotionality (2/15) (
Thompson,
1953). Nervous (
Staats, 1976).
Life-span and spontaneous disease
Short life-span in conventional conditions (4/22 = 421 days in males,
6/22 = 468 days in females) (
Storer, 1966).
Frequent mammary tumours, polycystic or granular kidneys (
Staats,
1976).
Normal physiology and biochemistry
High plasma cholesterol at 12 and 24 weeks (3/8) (
Weibust,
1973). Low porphyrin content of Harderian gland (2/16) (
Margolis,
1971). High susceptibility to audiogenic and electroconvulsive seizures
(2/6) (
Deckard et al., 1976., 1976).
High serum complement activity (c.f. 8/26) (
Ong
et al 1989)
Anatomy
Large kidney/body weight ratio (3/21) (
Schlager,
1968).
Drugs
Resistant to X-irradiation (8/27) (
Roderick, 1963).
Immunology
Erythrocytes have a high agglutinability (cf. 14/25) (
Rubinstein et al., 1974., 1974).
Infection
Murine acquired immune deficiency (MAIDS) is an immunosuppressive disease
of mice induced by infection with the LP-BM5 murine leukemia retrovirus.
Strain BDP has a novel disease phenotype with recovery of immune function
after a period of profound immune suppression. This is inherited as a
dominant character in crosses with both susceptible and resistant strains
(
Gilmore, 1997).
Deckard
B. S., Lieff B., Schlesinger K., and DeFries J. C. (1976) Developmental
patterns of seizure susceptibility in inbred strains of mice. Devel.
Psychobiol. 9, 17.
\par
Gilmore G. L. (1997)
Recovery from retrovirus-induced immune suppression in BDP/J mice: Dominance
of the 'regressor' phenotype. Immunol. 90, 7-13.
\par
Margolis F. L.
(1971) Regulation of porphyrin biosynthesis in the Harderian gland of
inbred mouse strains. Arch. Biochem. Biophys. 145, 373-381.
\par
Ong G. L. and
Mattes M. J. (1989) Mouse strains with typical mammalian levels of complement
activity. J. Immunol. Methods 125, 147-158.
\par
Roderick T. H.
(1963) The response of twenty-seven inbred strains of mice to daily doses
of whole-body X-irradiation. Radiation Res. 20, 631-639.
\par
Rubinstein
P., Liu N., Strenn E. W., and Decary F. (1974) Electrophoretic mobility
and agglutinability of red blood cells: a `new' polymorphism in mice.
J. Exp. Med. 139, 313-322.
\par
Schlager G. (1968)
Kidney weight in mice: strain differences and genetic determination. J.
Hered. 59, 171-174.
\par
Staats J. (1976) Standardized
nomenclature for inbred strains of mice: Sixth listing. Cancer Res.
36, 4333-4377.
\par
Storer J. B. (1966)
Longevity and gross pathology at death in 22 inbred strains of mice. J.
Gerontol. 21, 404-409.
\par
Thompson W. R.
(1953) The inheritance of behaviour: behavioural differences in fifteen
mouse strains. Can. J. Psychol. 7, 145-155.
\par
Weibust R. S. (1973)
Inheritance of plasma cholesterol levels in mice. Genetics 73,
303-312.
\par
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK
