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Symbol
Name
ID

Tnfrsf11a
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
MGI:1314891

Phenotype annotations related to skeleton

Darker colors indicate more annotations

Human Phenotypes

Sclerosis of skull base

Increased head circumference

Bowing of the long bones

Femoral bowing

Short femur

Femur fracture

Osteosclerosis of the ulna

Bone pain

Increased susceptibility to fractures

Pathologic fracture

Fractures of the long bones

Multiple rib fractures

Sandwich appearance of vertebral bodies

Vertebral compression fracture

Osteopetrosis

Osteoporosis

Thin bony cortex

Abnormal trabecular bone morphology

Osteolysis

Disease(s) Associated with TNFRSF11A

autosomal recessive osteopetrosis 7

familial expansile osteolysis

osteoporosis

Paget's disease of bone 2

Mouse Phenotypes

abnormal osteoclast differentiation

absent incisors

failure of tooth eruption

tooth impaction

domed cranium

decreased osteoclast cell number

increased osteoclast cell number

abnormal osteoclast morphology

abnormal osteoclast physiology

increased femoral compact bone area

abnormal tibia morphology

abnormal long bone hypertrophic chondrocyte zone

increased long bone epiphyseal plate size

abnormal long bone metaphysis morphology

increased diameter of long bones

kyphosis

abnormal bone structure

increased bone mineral density

increased trabecular bone volume

increased bone volume

decreased compact bone thickness

abnormal osteoblast morphology

increased osteoblast cell number

abnormal trabecular bone morphology

increased bone trabecula number

decreased bone trabecular spacing

increased trabecular bone thickness

osteopetrosis

osteosclerosis

abnormal skeleton physiology

abnormal bone mineralization

abnormal bone remodeling

Availability

Mouse Genotype

Tnfrsf11a^del8/Tnfrsf11a^del8

Tnfrsf11a^tm1.1Sral/Tnfrsf11a^tm1.1Sral

Tnfrsf11a^tm1.2Pngr/Tnfrsf11a^tm1.2Pngr

Tnfrsf11a^tm1Imx/Tnfrsf11a^tm1Imx

Tnfrsf11a^tm1Kost/Tnfrsf11a^tm1Kost

Tnfrsf11a^tm1Wjb/Tnfrsf11a^tm1Wjb

Tnfrsf11a^tm1.1Sral/Tnfrsf11a⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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