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Symbol
Name
ID
Lepr
leptin receptor
MGI:104993
Phenotype annotations related to growth/size/body
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Increased waist to hip ratio
Obesity
Disease(s) Associated with LEPR
coronary artery disease
obesity
type 2 diabetes mellitus

Mouse Phenotypes
increased body fat mass
heart left ventricle hypertrophy
growth/size/body region phenotype
increased birth weight
abnormal body composition
decreased lean body mass
increased lean body mass
decreased body weight
weight loss
increased body weight
obese
decreased body length
increased body length
abnormal body weight
increased susceptibility to weight gain
increased susceptibility to age related obesity
increased susceptibility to diet-induced obesity
increased body size
enlarged kidney
increased kidney weight
enlarged liver
increased liver weight
Availability Mouse Genotype
Leprbrta/Leprbrta
Leprdb-1R/Leprdb-1R
LeprDb-2Btlr/LeprDb-2Btlr
Leprdb-3J/Leprdb-3J
Leprdb-5J/Leprdb-5J
Leprdb-9J/Leprdb-9J
Leprdb-ad/Leprdb-ad
LeprDb-Btlr/LeprDb-Btlr
Leprdb-lb/Leprdb-lb
Leprdb-NCSU/Leprdb-NCSU
Leprdb-Nokl/Leprdb-Nokl
Leprdb-rtnd/Leprdb-rtnd
Leprdb/Leprdb
LeprKK/LeprKK
Leprm1Anu/Leprm1Anu
Leprm1Clo/Leprm1Clo
Leprm3Btlr/Leprm3Btlr
Leprm5Btlr/Leprm5Btlr
Leprm6Btlr/Leprm6Btlr
Leprm8Btlr/Leprm8Btlr
Leprm9Btlr/Leprm9Btlr
Leprm10Btlr/Leprm10Btlr
Leprtm1.1Chua/Leprtm1.1Chua *
Leprtm1.1Rck/Leprtm1.1Rck
Leprtm1.1Rll/Leprtm1.1Rll *
Leprtm1.2Chua/Leprtm1.2Chua
Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Leprtm1Chua/Leprtm1Chua
Leprtm1Jke/Leprtm1Jke
Leprtm1Mgmj/Leprtm1Mgmj
Leprtm1Yli/Leprtm1Yli
Leprtm2Mgmj/Leprtm2Mgmj
Leprtm2Yli/Leprtm2Yli
Leprtm3(cre)Mgmj/Leprtm3(cre)Mgmj *
Leprtm3.1Yli/Leprtm3.1Yli
Leprtm4Mgmj/Leprtm4Mgmj
Leprtm5Mgmj/Leprtm5Mgmj
LeprDb-2Btlr/Lepr+
LeprDb-Btlr/Lepr+
Leprdb/Lepr+
Leprdb/Leprdb-5J
Leprdb/Leprdb-Nokl
Leprm6Btlr/Lepr+
Leprtm1Mgmj/Lepr+
Leprtm3.1Yli/Lepr+
Leprm4Btlr/?
Leprtm1.1Chua/Leprtm1.1Chua
Tg(Pomc1-cre)16Lowl/0  (conditional)
Leprtm1.1Chua/Leprtm1.1Chua
Tg(Nr5a1-cre)2Lowl/0  (conditional)
Leprtm1.1Chua/Leprtm1.1Chua
Tg(Nr5a1-cre)7Lowl/0  (conditional)
Leprtm1.1Chua/Leprtm1.1Chua
Tg(Nr5a1-cre)2Lowl/0
Tg(Pomc1-cre)16Lowl/0  (conditional)
Leprtm1.1Chua/Leprtm1.1Chua
Tg(Gh1-cre)bKnmn/0  (conditional)
Leprtm1.1Chua/Leprtm1.1Chua
Slc17a6tm2(cre)Lowl/Slc17a6+  (conditional)
*
Leprtm1.1Chua/Leprtm1.1Chua
Slc32a1tm2(cre)Lowl/Slc32a1+  (conditional)
Leprtm1.1Chua/Leprtm1.1Chua
Ntstm1(cre)Mgmj/Nts+  (conditional)
Leprtm1.1Chua/Leprtm1.1Chua
Prlhtm1(cre)Smln/Prlh+  (conditional)
Leprtm1Jke/Leprtm1Jke
Tg(Pomc1-cre)16Lowl/0  (conditional)
Leprtm1.1Chua/Leprtm1.2Chua
Nos1tm1(cre)Mgmj/Nos1+  (conditional)
Leprtm1Rck/Leprtm1.1Rck
Tg(Syn1-cre)671Jxm/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory