mal de Meleda (DOID:0060862)
Alliance: disease page
Synonyms: keratosis palmoplantaris transgrediens of Siemens; Meleda disease; transgrediens palmoplantar keratoderma of Siemens
Alt IDs: OMIM:248300, ICD10CM:Q82.8, ORDO:87503
Definition: A palmoplantar keratosis characterized by autosomal recessive inheritance of symmetric palmoplantar hyperkeratosis that progressively extends to the dorsal surfaces of hands and feet and ichthyotic changes elsewhere that has_material_basis_in homozygous mutation in the SLURP1 gene on chromosome 8q24.