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Human Disease and Mouse Model Detail
Human Disease Frontotemporal Dementia; FTD
OMIM ID: 600274
Human Phenotype Ontology associations
Synonyms Dementia, Frontotemporal, with Parkinsonism; Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex; DDPAC; Frontotemporal Dementia; Frontotemporal Dementia with Parkinsonism; Frontotemporal Lobar Degeneration with Tau Inclusions; Frontotemporal Lobe Dementia; FLDEM; FTDP17; Ftld with Tau Inclusions; Multiple System Tauopathy with Presenile Dementia; MSTD; Wilhelmsen-Lynch Disease; WLD
View all models View ALL (20) mouse models for this human disease.
Genes and
mouse models
Mutations in human and/or mouse homologs are associated with this disease

      *Disease is associated/modeled with this Gene or a homolog. More...
      Human Homologs Mouse Homologs Mouse Models Homology Source
     MAPT* Mapt View 16 models HomoloGene and HGNC
PSEN1* Psen1   HomoloGene and HGNC
Transgenes and
other genome features
Transgenes and other genome features developed in mice to model this disease.

     Transgenes and Other Genome Features Mouse Models
  Tg(Camk2a-MAPT)601Ymot View 1 model
  Tg(Camk2a-MAPT*P301L)D35Jiri View 1 model
  Tg(Camk2a-MAPT*R406W)748Atak View 1 model
  Tg(MAPT*V337M)1Gds View 1 model
  Tg(PDGFB-MAPT*V337M)1Atak View 1 model
  Tg(Prnp-MAPT)7Vle View 1 model
  Tg(Prnp-MAPT)43Vle View 1 model
  Tg(Prnp-MAPT*P301L)JNPL3Hlmc View 1 model
  Tg(Prnp-MAPT*R406W)21807Dwst View 1 model
  Tg(Prnp-TARDBP*A315T)95Balo View 1 model
  Tg(tetO-MAPT*P301L)#Kha View 2 models
  Tg(Thy1-MAPT*)1Avil View 1 model
  Tg(Thy1-MAPT*K369I)K3Gotz View 1 model
  Tg(Thy1-MAPT*P301S)2541Godt View 1 model
  Tg(Thy1-MAPT*V337M)1Godt View 1 model
  Tg(Thy1-TARDBP)4Singh View 2 models
  Tg(Thy1-TARDBP)6Singh View 1 model
  Tg(Tuba1-MAPT)14Vle View 1 model
References Disease References using Mouse Models (20)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.07
The Jackson Laboratory