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Disease Ontology Browser
Werner syndrome (DOID:5688)
Synonyms: adult premature ageing syndrome; adult progeria; Werner's syndrome; WS
Alt IDs: OMIM:277700, MESH:D014898, NCI:C3447, ORDO:902, UMLS_CUI:C0043119
Definition: An autosomal recessive disease characterized by premature aging and age-related phenotypes such as atherosclerosis, arteriosclerosis, cataracts, osteoporosis, soft tissue calcification, premature thinning, graying, and loss of hair, as well as a high incidence of some types of cancers. In 90% of the cases it is that has material basis in mutations in the WRN gene, on chromosome 8.

Disease References using Mouse Models (4)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/14/2017
MGI 6.08
The Jackson Laboratory