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Gene Expression Data
Assay Details
Assay
Reference: J:156174 Ralston A, et al., Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2. Development. 2010 Feb;137(3):395-403
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6510821
Gene symbol: Gata3
Gene name: GATA binding protein 3
Results
Specimen 4A: embryonic day 2.5 (more )
Note: early 8-cell
Structure Level Pattern Image Note
TS3: 8-cell stage embryo Absent 4A Gata3/Nuclei , 4A Gata3

Specimen 4B: embryonic day 3.0 (more )
Note: 16-cell
Structure Level Pattern Image Note
TS3: compacted morula Present 4B Gata3/Nuclei , 4B Gata3 Expression correlated closely, but not completely with Cdx2.

Specimen 4C: embryonic day 3.0 (more )
Note: 32-cell
Structure Level Pattern Image Note
TS4: compacted morula Present 4C Gata3/Nuclei , 4C Gata3 Expression correlated closely, but not completely with Cdx2.

Specimen 4D: embryonic day 3.5 (more )
Note: Blastocyst
Structure Level Pattern Image Note
TS4: trophectoderm Present Regionally restricted 4D Gata3/Nuclei , 4D Gata3 Expression was detectable within the nucleiof the trophectoderm, where it colocalized with Cdx2.

Specimen 6A: embryonic day 3.5 (more )
Note: Blastocyst
Structure Level Pattern Image Note
TS4: trophectoderm Present 6A Gata3 , 6A Gata3/Nuclei

Specimen 6B: embryonic day 3.5; Tead4tm1Hssk/Tead4tm1Hssk (more )
Note: Blastocyst
Structure Level Pattern Image Note
TS4: trophectoderm Trace 6B Gata3 , 6B Gata3/Nuclei Nuclear levels of Gata3 were greatly reduced in Tead4 mutants. Low levels of Gata3 could be detected in the nuclei of some cells.

Specimen 6C: embryonic day 3.5 (more )
Note: Blastocyst
Structure Level Pattern Image Note
TS4: trophectoderm Present 6C Gata3/Nuclei , 6C Gata3

Specimen 6D: embryonic day 3.5; Cdx2tm1Fbe/Cdx2tm1Fbe (more )
Note: Blastocyst
Structure Level Pattern Image Note
TS4: trophectoderm Present 6D Gata3 , 6D Gata3/Nuclei Gata3 expression was unaffected by the loss of Cdx2.

Specimen 7C: embryonic day 3.5; Pou5f1tm1.1Scho/Pou5f1tm1.1Scho (more )
Structure Level Pattern Image Note
TS4: trophectoderm Present 7C Gata3 Gata3 expression pattern was largely unaffected in Pou5f1 mutants.
TS4: inner cell mass Absent 7C Gata3

Specimen 7D: embryonic day 4.25 (more )
Note: Implanting blastocyst.
Structure Level Pattern Image Note
TS6: epiblast Absent 7D Gata3 Expression was excluded from nuclei.
TS6: primitive endoderm Absent 7D Gata3 Expression was excluded from nuclei.

Specimen 7E: embryonic day 4.25; Pou5f1tm1.1Scho/Pou5f1tm1.1Scho (more )
Note: Implanting blastocyst.
Structure Level Pattern Image Note
TS6: epiblast Present 7E Gata3 Nuclear expression of Gata3 was upregulated in the mutant epiblast and primitive endoderm.
TS6: primitive endoderm Present 7E Gata3 Nuclear expression of Gata3 was upregulated in the mutant epiblast and primitive endoderm.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/12/2021
MGI 6.17
The Jackson Laboratory