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Gene Expression Data
Assay Details
Assay
Reference: J:270838 Wiederstein JL, et al., Skeletal Muscle-Specific Methyltransferase METTL21C Trimethylates p97 and Regulates Autophagy-Associated Protein Breakdown. Cell Rep. 2018 May 1;23(5):1342-1356
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6458580
Gene symbol: Myh7
Gene name: myosin, heavy polypeptide 7, cardiac muscle, beta
Antibody: anti-Myh7 (BA-FB)
Detection system: Alexa Fluor
Results
Specimen 1F MYH7 Mettl21c +/-: postnatal adult; Mettl21ctm1.1Krug/Mettl21c+ (more )
Structure Level Pattern Image Note
TS28: soleus Present Regionally restricted 1F MYH7 Mettl21c +/- Expression in slow muscle fibers.

Specimen 1F MYH7 Mettl21c -/-: postnatal adult; Mettl21ctm1.1Krug/Mettl21ctm1.1Krug (more )
Structure Level Pattern Image Note
TS28: soleus Present Regionally restricted 1F MYH7 Mettl21c -/- Expression in slow muscle fibers.

Specimen S1K MYH7 Wild type: postnatal adult (more )
Structure Level Pattern Image Note
TS28: soleus Present Regionally restricted S1K MYH7 Wild type Expression in slow muscle fibers.

Specimen S1K MYH7 Mettl21c +/-: postnatal adult; Mettl21ctm1.1Krug/Mettl21c+ (more )
Structure Level Pattern Image Note
TS28: soleus Present Regionally restricted S1K MYH7 Mettl21c +/- Expression in slow muscle fibers.

Specimen S1K MYH7 Mettl21c -/-: postnatal adult; Mettl21ctm1.1Krug/Mettl21ctm1.1Krug (more )
Structure Level Pattern Image Note
TS28: soleus Present Regionally restricted S1K MYH7 Mettl21c -/- Expression in slow muscle fibers.

Specimen S3D MYH7: postnatal adult (more )
Note: Double labeled: blue - Myh7; red - LC3 (assay MGI:6458592).
Structure Level Pattern Image Note
TS28: soleus Present Regionally restricted S3D MYH7 Expression in slow muscle fibers.

Specimen 5F MYH7 wild type (upper): postnatal adult (more )
Note: Double labeled: red - Myh7; blue - 3me-p97 (K315) (Vcp assay MGI:6458593).
Structure Level Pattern Image Note
TS28: soleus Present 5F wild type (upper left)

Specimen 5F MYH7 wild type (lower): postnatal adult (more )
Note: Double labeled: red - Myh7; blue - 3me-p97 (K315) (Vcp assay MGI:6458593).
Structure Level Pattern Image Note
TS28: soleus Present 5F wild type (lower left)

Specimen 5F MYH7 Mettl21c -/- (upper): postnatal adult; Mettl21ctm1.1Krug/Mettl21ctm1.1Krug (more )
Note: Double labeled: red - Myh7; blue - 3me-p97 (K315) (Vcp assay MGI:6458593).
Structure Level Pattern Image Note
TS28: soleus Present 5F Mettl21c -/- (upper left)

Specimen 5F MYH7 Mettl21c -/- (lower): postnatal adult; Mettl21ctm1.1Krug/Mettl21ctm1.1Krug (more )
Note: Double labeled: red - Myh7; blue - 3me-p97 (K315) (Vcp assay MGI:6458593).
Structure Level Pattern Image Note
TS28: soleus Present 5F Mettl21c -/- (lower left)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/19/2021
MGI 6.17
The Jackson Laboratory