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Gene Expression Data
Assay Details
Assay
Reference: J:159888 Sephton CF, et al., TDP-43 is a developmentally regulated protein essential for early embryonic development. J Biol Chem. 2010 Feb 26;285(9):6826-34
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:5438542
Gene symbol: Tardbp
Gene name: TAR DNA binding protein
Modification date: 02/17/2016
Reporter: lacZ
Direct Detection
Results
Specimen 5A.i.: embryonic day 9.5; TardbpGt(RRB030)Byg/Tardbp+ (more )
Note: Embryos were fixed in 1% paraformaldehyde, 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS15: embryo Present 5A.i
TS15: central nervous system Strong 5A.i There is strong expression throughout the neuroepithelium.

Specimen 5A.ii.: embryonic day 9.5; TardbpGt(RRB030)Byg/Tardbp+ (more )
Structure Level Pattern Image Note
TS15: neural tube lateral wall Present 5A.ii Expression is present in the neuroepithelium.

Specimen 5B.1: embryonic day 9.5; TardbpGt(RRB030)Byg/Tardbp+ (more )
Structure Level Pattern Image Note
TS15: future brain Strong Regionally restricted 5B.1 Expression is present in the neuroepithelium.

Specimen 5B.2: embryonic day 9.5; TardbpGt(RRB030)Byg/Tardbp+ (more )
Structure Level Pattern Image Note
TS15: future brain Strong Regionally restricted 5B.2 Expression is present in the neuroepithelium.

Specimen 5B.3: embryonic day 9.5; TardbpGt(RRB030)Byg/Tardbp+ (more )
Structure Level Pattern Image Note
TS15: 1st branchial arch Present 5B.3

Specimen 5B.4: embryonic day 9.5; TardbpGt(RRB030)Byg/Tardbp+ (more )
Structure Level Pattern Image Note
TS15: 2nd branchial membrane Present 5B.4
TS15: neural tube lateral wall Strong 5B.4 Expression is present in the neuroepithelium.

Specimen 5B.5: embryonic day 9.5; TardbpGt(RRB030)Byg/Tardbp+ (more )
Structure Level Pattern Image Note
TS15: bulbus cordis Present 5B.5
TS15: common atrial chamber Present 5B.5
TS15: vitelline artery Present 5B.5
TS15: neural tube lateral wall Strong 5B.5 Expression is present in the neuroepithelium.

Specimen 5B.6: embryonic day 9.5; TardbpGt(RRB030)Byg/Tardbp+ (more )
Structure Level Pattern Image Note
TS15: pericardio-peritoneal canal Present 5B.6 Expression is present in the left and right pericardio-peritoneal canal.
TS15: hindgut Present 5B.6
TS15: neural tube lateral wall Strong 5B.6 Expression is present in the neuroepithelium.

Specimen 5B.7: embryonic day 9.5; TardbpGt(RRB030)Byg/Tardbp+ (more )
Structure Level Pattern Image Note
TS15: somite Present 5B.7
TS15: neural tube lateral wall Strong 5B.7 Expression is present in the neuroepithelium.

Specimen 5B.8: embryonic day 9.5; TardbpGt(RRB030)Byg/Tardbp+ (more )
Structure Level Pattern Image Note
TS15: somite Present 5B.8
TS15: neural tube lateral wall Strong 5B.8 Expression is present in the neuroepithelium.

Specimen 6B.i: embryonic day 10.5; TardbpGt(RRB030)Byg/Tardbp+ (more )
Note: Embryos were fixed in 1% paraformaldehyde, 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS17: forelimb bud Strong 6B.i.
TS17: hindlimb bud Strong 6B.i.

Specimen 6B.ii: embryonic day 10.5; TardbpGt(RRB030)Byg/Tardbp+ (more )
Note: Embryos were fixed in 1% paraformaldehyde, 0.2% glutaraldehyde.
Structure Level Pattern Image Note
TS17: future spinal cord Strong 6B.ii.
TS17: hindbrain Strong 6B.ii.
TS17: midbrain Strong 6B.ii.

Specimen 6B.iii: embryonic day 10.5; TardbpGt(RRB030)Byg/Tardbp+ (more )
Structure Level Pattern Image Note
TS17: neural tube lateral wall Present 6B.iii. Expression is present in the neuroepithelium.

Specimen 6C.i: embryonic day 12.5; TardbpGt(RRB030)Byg/Tardbp+ (more )
Structure Level Pattern Image Note
TS20: spinal cord ventricular layer Present 6C.i. Expression is present in spinal progenitors.
TS20: spinal cord lateral wall Present Regionally restricted 6C.i. Expression is present in the motor neurons of the ventral horn.
TS20: dorsal root ganglion Present 6C.i.

Specimen 6C.ii: embryonic day 12.5; TardbpGt(RRB030)Byg/Tardbp+ (more )
Structure Level Pattern Image Note
TS20: brain ventricular layer Strong 6C.ii. Expresion is present in progenitors.
TS20: eye Present 6C.ii.

Specimen 7i.: postnatal adult; TardbpGt(RRB030)Byg/Tardbp+ (more )
Structure Level Pattern Image Note
TS28: neocortex Strong 7i

Specimen 7ii.: postnatal adult; TardbpGt(RRB030)Byg/Tardbp+ (more )
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Strong 7ii
TS28: cerebellum granule cell layer Strong 7ii

Specimen 7iii.: postnatal adult; TardbpGt(RRB030)Byg/Tardbp+ (more )
Structure Level Pattern Image Note
TS28: dentate gyrus Strong 7iii
TS28: hippocampus Strong 7iii
TS28: hippocampus CA1 Strong 7iii
TS28: hippocampus CA3 Strong 7iii

Specimen 7iv.: postnatal adult; TardbpGt(RRB030)Byg/Tardbp+ (more )
Structure Level Pattern Image Note
TS28: main olfactory bulb glomerular layer Present 7iv

Specimen 7v.: postnatal adult; TardbpGt(RRB030)Byg/Tardbp+ (more )
Structure Level Pattern Image Note
TS28: spinal cord Present 7v Staining is obsered throughout the spinal cord, mostly in the dorsal horn and, to a lesser extent, the ventral horn.
TS28: spinal cord dorsal horn Present 7v Staining is obsered throughout the spinal cord, mostly in the dorsal horn and, to a lesser extent, the ventral horn.
TS28: spinal cord ventral horn Present 7v Staining is obsered throughout the spinal cord, mostly in the dorsal horn and, to a lesser extent, the ventral horn.

Specimen 7vi.: postnatal adult; TardbpGt(RRB030)Byg/Tardbp+ (more )
Structure Level Pattern Image Note
TS28: bronchiole Present 7vi

Specimen 7vii.: postnatal adult; TardbpGt(RRB030)Byg/Tardbp+ (more )
Structure Level Pattern Image Note
TS28: ovary Present Widespread 7vii
TS28: oocyte Present 7vii

Specimen 7viii.: postnatal adult; TardbpGt(RRB030)Byg/Tardbp+ (more )
Structure Level Pattern Image Note
TS28: testis Present 7viii
TS28: Sertoli cell Present 7viii Expression is present at the periphery, where the Sertoli cells are found.
TS28: Leydig cell Present 7viii There is some staining of Leydig cells.

Specimen 7ix.: postnatal adult; TardbpGt(RRB030)Byg/Tardbp+ (more )
Structure Level Pattern Image Note
TS28: renal cortex Present 7ix Expression in the kidney is concentrated in the cortical region.

Specimen 7x.: postnatal adult; TardbpGt(RRB030)Byg/Tardbp+ (more )
Structure Level Pattern Image Note
TS28: liver Moderate 7x Expression is present in the hepatocytes.

Specimen 7xi.: postnatal adult; TardbpGt(RRB030)Byg/Tardbp+ (more )
Structure Level Pattern Image Note
TS28: heart Moderate Widespread 7xi


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/09/2018
MGI 6.12
The Jackson Laboratory