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Gene Expression Data
Assay Details
Assay
Reference: J:106092 Tissir F, et al., Expression of planar cell polarity genes during development of the mouse CNS. Eur J Neurosci. 2006 Feb;23(3):597-607
Assay type: RNA in situ
MGI Accession ID: MGI:4946668
Gene symbol: Prickle1
Gene name: prickle planar cell polarity protein 1
Probe: Prickle1 cDNA2
Probe preparation: Antisense RNA labelled with P33
Visualized with: Autoradiography
Results
Specimen 1H: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: nervous system Moderate 1H Neural expression was relatively higher in postmitotic differentiation fields than in ventricular zones.
TS17: limb Present 1H
TS17: embryo Present Non-Uniform 1H Expression was detected at moderate intensity in neural tissue, and to a lesser level in non-neural tissue, particularly in limb buds.

Specimen 2U: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: cartilage Strong 2U
TS20: ganglion Moderate 2U
TS20: skin Moderate 2U

Specimen 2V & 2W: embryonic day 12.5 (more )
Note: Fig. 2W is a higher magnification image of the boxed region if Fig. 2V.
Structure Level Pattern Image Note
TS20: brain Present Regionally restricted 2V , 2W Expression was restricted to periventricular and paramedian nuclei of the brainstem.

Specimen not shown: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: cartilage Strong
TS22: brain Weak Regionally restricted The brain was mostly unlabelled, with the exception of the immature facial nerve nucleus in the brainstem and the cortical plate.
TS22: brainstem Weak Regionally restricted The brain was mostly unlabelled, with the exception of the immature facial nerve nucleus in the brainstem and the cortical plate.
TS22: cortical plate Weak

Specimen Table 2: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: brainstem Present Regionally restricted Expression was present in the reticular formation but was very low or undetectable in the cochleovestibular nuclei.
TS25: cerebellum Ambiguous Regionally restricted Expression was very low or undetectable in the external granule layer.
TS25: diencephalon ventricular layer Ambiguous Expression was very low or undetectable.
TS25: hypothalamus Ambiguous Expression was very low or undetectable.
TS25: midbrain tegmentum Ambiguous Expression was very low or undetectable.
TS25: midbrain ventricular layer Ambiguous Expression was very low or undetectable.
TS25: tectum Ambiguous Expression was very low or undetectable.
TS25: thalamus Ambiguous Regionally restricted Expression was very low or undetectable in the dorsal and ventral thalamus.
TS25: retina Ambiguous Regionally restricted Expression was very low or undetectable in the ventricular zone and ganglion cells.
TS25: cortical plate Present Regionally restricted Expression was detected in the cortical plate proper but was very low or undetectable in the cortical plate ventricular zone/subventricular zone.
TS25: corpus striatum Ambiguous Regionally restricted Expression was very low or undetectable in the striatum ventricular zone/subventricular zone and in the striatum.
TS25: main olfactory bulb Ambiguous Regionally restricted Expression was very low or undetectable in the olfactory bulb and in mitral cells.

Specimen 4G1: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: cartilage Present 4G1
TS25: lens Present 4G1
TS25: medulla oblongata Strong Regionally restricted 4G1 A very high signal was associated specifically with the inferior olivary complex.

Specimen 4G2: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: cortical plate Moderate Regionally restricted 4G2 Expression was detected in the medial and dorsal sectors of the cortical plate.

Specimen 5K & 5L: postnatal day 0 (more )
Note: Fig. 5L is a higher magnification image of the boxed region in 5K.
Structure Level Pattern Image Note
TS27: brain Weak 5K
TS27: cerebral cortex Moderate Regionally restricted 5K Expression was moderate in the cortical plate.
TS27: inferior olivary nucleus Very strong 5L , 5K

Specimen Table 3: postnatal day 10 (more )
Structure Level Pattern Image Note
TS28: cerebellum external granule cell layer Ambiguous Expression was very low or undetectable.
TS28: diencephalon Ambiguous Regionally restricted Expression was very low or undetectable in the diencephalon ventricular zone.
TS28: dentate gyrus Present
TS28: dorsal thalamus Present
TS28: hippocampus pyramidal cell layer Present
TS28: main olfactory bulb mitral cell layer Present
TS28: hypothalamus Ambiguous Expression was very low or undetectable.
TS28: prethalamus Ambiguous Expression was very low or undetectable.
TS28: cerebral cortex Present Regionally restricted Expression was detected in the cortical plate proper but was very low or undetectable in the cortical plate ventricular zone/subventricular zone.
TS28: corpus striatum Ambiguous Expression was very low or undetectable in the striatum and the ventricular zone/subventricular zone.
TS28: rostral migratory stream Ambiguous Expression was very low or undetectable in the rostral migratory stream.
TS28: main olfactory bulb granule cell layer Strong

Specimen 6S: postnatal day 10 (more )
Structure Level Pattern Image Note
TS28: neocortex Present Regionally restricted 6S Expression was detected in the inner aspect of the cortical plate but not in periventricular layers.

Specimen 6T: postnatal day 10 (more )
Structure Level Pattern Image Note
TS28: hippocampus Present 6T

Specimen 6U: postnatal day 10 (more )
Structure Level Pattern Image Note
TS28: main olfactory bulb granule cell layer Strong 6U
TS28: main olfactory bulb Present Regionally restricted 6U Expression was detected in the granular layer of the olfactory bulb but the rostral migratory stream was negative.
TS28: neocortex Present Regionally restricted 6U Expression was detected in the inner aspect of the cortical plate in the neocortex but was negative in the rostral migratory stream.
TS28: rostral migratory stream Absent 6U

Specimen not shown: postnatal day 10 (more )
Structure Level Pattern Image Note
TS28: inferior olivary nucleus Present

Specimen 7G: postnatal day 21 (more )
Structure Level Pattern Image Note
TS28: telencephalon Present 7G
TS28: cerebral cortex Moderate Diffuse 7G
TS28: dentate gyrus Moderate Diffuse 7G
TS28: hippocampus pyramidal cell layer Moderate Diffuse 7G
TS28: main olfactory bulb granule cell layer Moderate Diffuse 7G


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/12/2021
MGI 6.17
The Jackson Laboratory