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Gene Expression Data
Assay Details
Assay
Reference: J:117061 Goebbels S, et al., Genetic targeting of principal neurons in neocortex and hippocampus of NEX-Cre mice. Genesis. 2006 Dec;44(12):611-21
Assay type: Recombinase reporter
MGI Accession ID: MGI:4429135
Gene symbol: Neurod6
Gene name: neurogenic differentiation 6
Reporter: lacZ
Direct Detection
Results
Specimen not shown: embryonic day 10.5; Neurod6tm1(cre)Kan/Neurod6+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS17: embryo Absent
Specimen Fig. 2a: embryonic day 12.0; Neurod6tm1(cre)Kan/Neurod6+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: telencephalon Present Graded 2a Staining is observed in increasing numbers of cells in a medial to lateral gradient outside the ventricular zone close to the surface of the dorsal telencephalon.
TS20: cerebellum primordium Moderate 2a Staining is observed in the cerebellar anlage.
TS20: facial ganglion Moderate 2a
TS20: spinal cord Moderate 2a
Specimen Fig. 2b: embryonic day 12.0; Neurod6tm1(cre)Kan/Neurod6+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: telencephalon Present Graded 2b Staining is observed in increasing numbers of cells in a medial to lateral gradient outside the ventricular zone close to the surface of the dorsal telencephalon.
Specimen Fig. 2c: embryonic day 12.0; Neurod6tm1(cre)Kan/Neurod6+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: spinal cord Moderate 2c
TS20: cerebellum primordium Moderate 2c Staining is observed in the cerebellar anlage.
TS20: facial ganglion Moderate 2c
Specimen not shown: embryonic day 12.0; Neurod6tm1(cre)Kan/Neurod6+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: trigeminal ganglion Present Single cells Staining is observed in a few cells in the ganglia of the Vth cranial nerve.
Specimen Fig. 2g: embryonic day 16.5; Neurod6tm1(cre)Kan/Neurod6+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: telencephalon Present Regionally restricted 2g Staining is observed in the dorsal telencephalon.
TS24: hypothalamus Present Patchy 2g Staining is observed in domains of the hypothalamus.
TS24: pons Present Patchy 2g Staining is observed in domains of the pons.
Specimen Fig. 2h: embryonic day 16.5; Neurod6tm1(cre)Kan/Neurod6+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: dorsal root ganglion Present Scattered 2h
Specimen not shown: postnatal day 1; Neurod6tm1(cre)Kan/Neurod6+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: neocortex Present Regionally restricted Staining is observed in the subplate (layer VII) but not in marginal zone cells.
Specimen Fig. 3b: postnatal adult; Neurod6tm1(cre)Kan/Neurod6+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: superior colliculus Strong 3b
TS28: periaqueductal grey Strong 3b
TS28: pontine nucleus Strong 3b
TS28: nucleus of darkschewitsch Present 3b
Specimen Fig. 3c: postnatal adult; Neurod6tm1(cre)Kan/Neurod6+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: trigeminal V spinal sensory nucleus Present 3c Staining is observed in the spinal trigeminal nucleus.
TS28: vestibular nucleus Present 3c
TS28: cochlear nucleus Present 3c Staining is observed in the cochlear nucleus.
TS28: deep cerebellar nucleus Present 3c
Specimen Fig. 3f: postnatal adult; Neurod6tm1(cre)Kan/Neurod6+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: main olfactory bulb glomerular layer Present 3f Staining is observed in the periglomerular layer of the olfactory bulb.
TS28: main olfactory bulb mitral cell layer Present 3f
TS28: anterior olfactory nucleus Strong 3f Staining is observed in the ventral anterior olfactory nucleus.
Specimen Fig. 3g: postnatal adult; Neurod6tm1(cre)Kan/Neurod6+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: habenula Present 3g Staining is observed in the habenular nuclei.
Specimen Fig. 3h: postnatal adult; Neurod6tm1(cre)Kan/Neurod6+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: lateral amygdaloid nucleus Strong 3h
TS28: basolateral amygdaloid nucleus Strong 3h
TS28: basomedial amygdaloid nucleus Strong 3h
TS28: cortical amygdaloid nucleus Strong 3h
TS28: piriform cortex Strong 3h
Specimen Fig. 3i: postnatal adult; Neurod6tm1(cre)Kan/Neurod6+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: supramammillary nucleus Present 3i
Specimen Fig. 3j: postnatal adult; Neurod6tm1(cre)Kan/Neurod6+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: cerebellum granule cell layer Present 3j
Specimen Fig. 3k: postnatal adult; Neurod6tm1(cre)Kan/Neurod6+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: trigeminal V spinal sensory nucleus Present 3k
TS28: cuneate nucleus Present 3k Staining is observed in the external cuneate nucleus.
TS28: lateral reticular nucleus Present 3k
TS28: solitary tract nucleus Present 3k
TS28: hypoglossal nucleus Present Regionally restricted 3k Staining is observed in the nucleus of roller.
Specimen not shown: postnatal adult; Neurod6tm1(cre)Kan/Neurod6+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: anterior commissure Absent Staining is absent from white matter structures such as the anterior commissure, hippocampal fimbria, and corpus callosum.
TS28: corpus callosum Absent Staining is absent from white matter structures such as the anterior commissure, hippocampal fimbria, and corpus callosum.
TS28: fimbria hippocampus Absent Staining is absent from white matter structures such as the anterior commissure, hippocampal fimbria, and corpus callosum.
TS28: substantia nigra Absent
TS28: caudate nucleus Absent Staining is not observed in the caudate or putamen.
TS28: putamen Absent Staining is not observed in the caudate or putamen.
Specimen Fig. 4a bottom pane: postnatal day 59; Neurod6tm1(cre)Kan/Neurod6+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: dentate gyrus Present Regionally restricted 4a bottom
TS28: dentate gyrus granule cell layer Absent 4a bottom Staining is not observed in newborn cells within the subgranular zone.
Specimen Fig. 5a A: postnatal day 20; Neurod6tm1(cre)Kan/Neurod6+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: neocortex Present Regionally restricted 5aA Staining is observed in neurons, but not oligodendrocytes.
TS28: hippocampus CA1 Present Regionally restricted 5aA Staining is observed in neurons, but not oligodendrocytes.
Specimen Fig. 5a B: postnatal day 20; Neurod6tm1(cre)Kan/Neurod6+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: telencephalon Present Regionally restricted 5aB Staining is observed in projection neurons in the dorsal telencephalon.
Specimen Fig. 5a C: postnatal day 20; Neurod6tm1(cre)Kan/Neurod6+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: neocortex Present Regionally restricted 5aC Staining is observed in neurons, but not oligodendrocytes.
TS28: hippocampus CA1 Present Regionally restricted 5aC Staining is observed in neurons, but not oligodendrocytes.
Specimen Fig. 5a D: postnatal day 20; Neurod6tm1(cre)Kan/Neurod6+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: telencephalon Present Regionally restricted 5aD Staining is observed in projection neurons in the dorsal telencephalon.
Specimen Fig. 5a E: postnatal day 20; Neurod6tm1(cre)Kan/Neurod6+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: hippocampus CA1 Present Regionally restricted 5aE Staining is not observed in astrocytes.
Specimen Fig. 5a F: postnatal day 13; Neurod6tm1(cre)Kan/Neurod6+, Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: brain Present Regionally restricted 5aF Staining is observed in neurons, colocalizing with NeuN staining.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
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