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Gene Expression Data
Assay Details
Assay
Reference: J:76005 Gu Y, et al., Impaired conditioned fear and enhanced long-term potentiation in Fmr2 knock-out mice. J Neurosci. 2002 Apr 1;22(7):2753-63
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:3656053
Gene symbol: Aff2
Gene name: AF4/FMR2 family, member 2
Reporter: lacZ
Direct Detection
Results
Specimen 3A: embryonic day 10.5; Aff2tm1Dln/Aff2tm1Dln (more )
Note: The authors did not specify the sex of this animal. Since this gene is carried on the X chromosome, it is possible that only one copy of this gene was present in the animal examined.
Structure Level Pattern Image Note
TS17: telencephalon Present Regionally restricted 3A Expression is present in the ganglionic eminences of the telencephalon, including the lateral and medial ganglionic eminences. There is no staining in most of the rest of the telencephalon.

Specimen Not shown: embryonic day 10.5; Aff2tm1Dln/Aff2tm1Dln (more )
Note: The authors did not specify the sex of this animal. Since this gene is carried on the X chromosome, it is possible that only one copy of this gene was present in the animal examined.
Structure Level Pattern Image Note
TS17: future spinal cord Present Single cells Expression is present in some neuroblast cells in the spinal cord.

Specimen 3B: embryonic day 12.5; Aff2tm1Dln/Aff2tm1Dln (more )
Note: The authors did not specify the sex of this animal. Since this gene is carried on the X chromosome, it is possible that only one copy of this gene was present in the animal examined.
Structure Level Pattern Image Note
TS20: cerebral cortex intermediate zone Present 3B Expression is concentrated in the germinal ventricular zone and the preplate; there are a few expressing cells in the intermediate zone.
TS20: cerebral cortex ventricular layer Present 3B Expression is concentrated in the germinal ventricular zone and the preplate; there are a few expressing cells in the intermediate zone.
TS20: cortical plate Present 3B Expression is concentrated in the germinal ventricular zone and the preplate; there are a few expressing cells in the intermediate zone.

Specimen 3C: embryonic day 15.0-15.5; Aff2tm1Dln/Aff2tm1Dln (more )
Note: The authors did not specify the sex of this animal. Since this gene is carried on the X chromosome, it is possible that only one copy of this gene was present in the animal examined.
Structure Level Pattern Image Note
TS23: cortical plate Strong 3C
TS23: cerebral cortex marginal layer Absent 3C

Specimen Not shown: embryonic day 15.0-15.5; Aff2tm1Dln/Aff2tm1Dln (more )
Note: The authors did not specify the sex of this animal. Since this gene is carried on the X chromosome, it is possible that only one copy of this gene was present in the animal examined.
Structure Level Pattern Image Note
TS23: embryo Present Under gross examination, expression appears to be present throughout the body. It is especially strong in the head and the extremeties.
TS23: head Strong

Specimen 3D: postnatal adult; Aff2tm1Dln/Aff2tm1Dln (more )
Note: The authors did not specify the sex of this animal. Since this gene is carried on the X chromosome, it is possible that only one copy of this gene was present in the animal examined.
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Present 3D

Specimen 3E: postnatal adult; Aff2tm1Dln/Aff2tm1Dln (more )
Note: The authors did not specify the sex of this animal. Since this gene is carried on the X chromosome, it is possible that only one copy of this gene was present in the animal examined.
Structure Level Pattern Image Note
TS28: hippocampus CA1 Strong 3E , 3F
TS28: hippocampus CA3 Strong 3E
TS28: dentate gyrus Strong 3E , 3F
TS28: amygdala Present 3E

Specimen Not shown: postnatal adult; Aff2tm1Dln/Aff2tm1Dln (more )
Note: The authors did not specify the sex of this animal. Since this gene is carried on the X chromosome, it is possible that only one copy of this gene was present in the animal examined.
Structure Level Pattern Image Note
TS28: bone Present
TS28: cardiac muscle tissue Present
TS28: caudate nucleus Present
TS28: cerebral cortex Present
TS28: ciliary body Present
TS28: conjunctival sac Present
TS28: corpus striatum Present
TS28: entorhinal cortex Present
TS28: epithalamus Present
TS28: main olfactory bulb Present
TS28: salivary gland Present
TS28: tendon Present
TS28: thalamus Present
TS28: tongue Present
TS28: cartilage Strong
TS28: hair follicle Strong Expression is strong in the mesenchymal cells of the papilla.
TS28: lung alveolus Present Single cells Expression is present in some alveolar cells in the lung.
TS28: blood vessel Present Expression is present in major blood vessels.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/19/2021
MGI 6.17
The Jackson Laboratory