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Gene Expression Data
Assay Details
Assay
Reference: J:104158 Alanentalo T, et al., Cloning and analysis of Nkx6.3 during CNS and gastrointestinal development. Gene Expr Patterns. 2006 Jan;6(2):162-70
Assay type: RNA in situ
MGI Accession ID: MGI:3614651
Gene symbol: Nkx6-3
Gene name: NK6 homeobox 3
Probe: Nkx6-3 cDNA1
Probe preparation: Antisense RNA
Results
Specimen Not Shown: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: hindbrain Present Regionally restricted Expression is in a small population of post-mitotic neurons in the ventral hindbrain.

Specimen 3A: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: hindbrain Present Regionally restricted 3A Expression is in the caudal hindbrain.

Specimen 3B: embryonic day 11.5 (more )
Note: Flat mount.
Structure Level Pattern Image Note
TS19: hindbrain Present Regionally restricted 3B Expression is extending from the boundary of rhombomere 5/6 to the hindbrain/spinal cord boundary.

Specimen 3C: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: hindbrain Present Regionally restricted 3C Expression is in the caudal hindbrain.

Specimen 3D: embryonic day 12.5 (more )
Note: This section is double labeled - Nkx6-3 (green, in situ); Lhx3 (red, immunofluorescence) as shown in assay MGI:3615109.
Structure Level Pattern Image Note
TS20: hindbrain Present Regionally restricted 3D Expression is in the caudal hindbrain.

Specimen 3E: embryonic day 12.5 (more )
Note: This section is double labeled - Nkx6-3 (green, in situ); Chx10 (red, immunofluorescence) as shown in assay MGI:3615114.
Structure Level Pattern Image Note
TS20: hindbrain Present Regionally restricted 3E Expression is in the caudal hindbrain.

Specimen 3F: embryonic day 12.5 (more )
Note: Double in situ analyses with Nkx6-3 (green); Nkx6-1 (red) as shown in MGI:3614671.
Structure Level Pattern Image Note
TS20: hindbrain Present Regionally restricted 3F Expression is in the caudal hindbrain.

Specimen 3G: embryonic day 12.5 (more )
Note: Double in situ analyses with Nkx6-3 (green); Nkx6-2 (red) as shown in MGI:3614855.
Structure Level Pattern Image Note
TS20: hindbrain Present Regionally restricted 3G Expression is in the caudal hindbrain.

Specimen 3L: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: hindbrain Present Regionally restricted 3L Expression is in the caudal hindbrain.

Specimen 3M: embryonic day 12.5; Nkx6-1tm1Jlr/Nkx6-1tm1Jlr (more )
Structure Level Pattern Image Note
TS20: hindbrain Present Regionally restricted 3M The region of expression is in the caudal hindbrain is reduced in this mutant.

Specimen 3N: embryonic day 12.5; Nkx6-2tm1Ercs/Nkx6-2tm1Ercs (more )
Structure Level Pattern Image Note
TS20: hindbrain Present Regionally restricted 3N Expression is in the caudal hindbrain. Expression in this mutant is the same as in wild-type embryos.

Specimen 4C: embryonic day 9.5 (more )
Structure Level Pattern Image Note
TS15: foregut-midgut junction Absent 4C Expression is absent in the pancreatic epithelium, stomach and duodenal endoderm.

Specimen 4F: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: foregut-midgut junction Present Regionally restricted 4F Expression is in the duodenal region and is absent in the pancreatic epithelium.
TS17: pancreas primordium Absent 4F Expression is in the duodenal region and is absent in the pancreatic epithelium.
TS17: stomach Present Regionally restricted 4F Expression is caudal.

Specimen 4I: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: foregut-midgut junction Present Regionally restricted 4I Expression is in the duodenal region and is absent in the pancreatic epithelium.
TS17: pancreas primordium Absent 4I Expression is in the duodenal region and is absent in the pancreatic epithelium.
TS17: stomach Present Regionally restricted 4I Expression is caudal.

Specimen 4L: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: pancreas Absent 4L

Specimen 5C: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: stomach glandular region epithelium Present Regionally restricted 5C Expression is in the caudal stomach.
TS20: foregut duodenum Present Regionally restricted 5C Expression is in the anterior portion.

Specimen 5F,I: embryonic day 16.5 (more )
Note: (G)-(I) shows high magnification of the glandular stomach and duodenum (inset) seen in (D)-(F).
Structure Level Pattern Image Note
TS24: stomach glandular region epithelium Present 5I , 5F
TS24: duodenum Present Regionally restricted 5F Expression is in the proximal duodenum.

Specimen 5I inset: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: duodenum Present Regionally restricted 5I inset Expression is in the proximal duodenum.

Specimen 5L: postnatal newborn (more )
Structure Level Pattern Image Note
TS27: stomach Present Regionally restricted 5L Expression is at the base of the gastric units.

Specimen 5O: postnatal adult (more )
Structure Level Pattern Image Note
TS28: stomach Present Regionally restricted 5O Expression is at the base of the gasrtic units.

Specimen 6C: postnatal newborn (more )
Structure Level Pattern Image Note
TS27: stomach Present Regionally restricted 6C Expression is predominantly in the crypts of the gastric units.

Specimen S1R: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: neural tube basal columns Absent S1_R


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/12/2021
MGI 6.17
The Jackson Laboratory