Lypla2tm1b(KOMP)Mbp
Targeted Allele Detail
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Symbol: |
Lypla2tm1b(KOMP)Mbp |
Name: |
lysophospholipase 2; targeted mutation 1b, Mouse Biology Program, UC Davis |
MGI ID: |
MGI:6271995 |
Synonyms: |
Lypla2Cre |
Gene: |
Lypla2 Location: Chr4:135695535-135699937 bp, - strand Genetic Position: Chr4, 68.33 cM, cytoband D3
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Alliance: |
Lypla2tm1b(KOMP)Mbp page
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IMPC: |
Lypla2 gene page |
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Germline Transmission: |
Earliest citation of germline transmission:
J:268038
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Parent Cell Line: |
JM8A1.N3 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
KOMP-CSD
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The L1L2_Bact_P cassette was inserted at position 135696246 of Chromosome 4 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 135698686. The critical exon(s) is/are thus flanked by loxP sites.A null/knockout allele was created by cre recombinase expression in mice carrying the tm1a allele to remove the neo selection cassette and loxP-flanked critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:268038)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Lypla2 Mutation: |
12 strains or lines available
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Original: |
J:268038 Won SJ, et al., Temporal Profiling Establishes a Dynamic S-Palmitoylation Cycle. ACS Chem Biol. 2018 Jun 15;13(6):1560-1568 |
All: |
1 reference(s) |
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