Summary | Mutation origin | Mutation description | Expression | Find Mice (IMSR) | References

Symbol:	Nr3c1tm1.2Jda
Name:	nuclear receptor subfamily 3, group C, member 1; targeted mutation 1.2, Jonathan D Ashwell
MGI ID:	MGI:6158660
Synonyms:	GR-null
Gene:	Nr3c1  Location: Chr18:39543598-39652474 bp, - strand  Genetic Position: Chr18, 21.09 cM
Alliance:	Nr3c1tm1.2Jda page

Germline Transmission:	Earliest citation of germline transmission: J:261396
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129 and C57BL/6

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intergenic deletion   Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 3 and a second loxP site downstream of exon 3, followed by a frt-flanked neomycin resistance (neo) cassette. Flp-mediated recombination remvoed the neo cassette. Resulting parental mice with allele Nr3c1tm1.1Jda were crossed with actin-cre mice to delete exon 3. Mice were backcrossed to breeding out the cre transgene. (J:261396)

In Mice Carrying this Mutation:

1 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr3c1 Mutation:	34 strains or lines available

Original:	J:261396 Bauerle KT, et al., Glucocorticoid Receptor Signaling Is Not Required for In Vivo Adipogenesis. Endocrinology. 2018 May 1;159(5):2050-2061
All:	1 reference(s)