Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hyal3tm1Btr
Name:	hyaluronoglucosaminidase 3; targeted mutation 1, Barbara Triggs-Raine
MGI ID:	MGI:6108181
Gene:	Hyal3  Location: Chr9:107458495-107464558 bp, + strand  Genetic Position: Chr9, 58.19 cM
Alliance:	Hyal3tm1Btr page

Germline Transmission:	Earliest citation of germline transmission: J:144606
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette (neo) was inserted into exon 2 of the gene at the NsiI site. This targeting construct was designed to disrupt Hyal3 while having minimal impact on an overlapping gene, Nat6 (N-acetyltransferase 6), which second exon is embedded within the first intron of this gene. RT-PCR analysis showed that no wild type transcript is expressed from this allele, and that Fus2 trasncripts are not altered in testis, but the levels are reduced about 20% in liver. (J:144606)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hyal3 Mutation:	11 strains or lines available

Original:	J:144606 Atmuri V, et al., Hyaluronidase 3 (HYAL3) knockout mice do not display evidence of hyaluronan accumulation. Matrix Biol. 2008 Oct;27(8):653-60
All:	1 reference(s)