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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hyal3tm1Btr
targeted mutation 1, Barbara Triggs-Raine
MGI:6108181
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hyal3tm1Btr/Hyal3tm1Btr 129-Hyal3tm1Btr MGI:6108354
hm2
 		Hyal3tm1Btr/Hyal3tm1Btr involves: 129 * CD-1 MGI:6108352


Genotype
MGI:6108354
hm1
Allelic
Composition		 Hyal3tm1Btr/Hyal3tm1Btr
Genetic
Background		 129-Hyal3tm1Btr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hyal3tm1Btr mutation (0 available); any Hyal3 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:144606 )
N
• glycosaminoglycan levels in liver, kidney, spleen, skin, testis, lung, fat and seminal vesicle
• circulating hyaluronic acid level in serum

respiratory system
impaired lung alveolus development ( J:144606 )
• more immature alveoli at 6 months




Genotype
MGI:6108352
hm2
Allelic
Composition		 Hyal3tm1Btr/Hyal3tm1Btr
Genetic
Background		 involves: 129 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hyal3tm1Btr mutation (0 available); any Hyal3 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:144606 )
N
• glycosaminoglycan levels in liver, kidney, spleen, skin, testis, lung, fat, seminal vesicle and knee joints
• circulating hyaluronic acid level in serum

respiratory system
abnormal lung interstitium morphology ( J:144606 )
• larger proportion of lung area with thickened interstitium at 12-14 months




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory