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Relntm1.1Mhat
Targeted Allele Detail
Nomenclature
Symbol: Relntm1.1Mhat
Name: reelin; targeted mutation 1.1, Mitsuharu Hattori
MGI ID: MGI:5774964
Synonyms: deltaC-KI
Gene: Reln  Location: Chr5:21884454-22344702 bp, - strand  Genetic Position: Chr5, 9.98 cM, cytoband A3-B1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:220151
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 65 was replaced with a FLAG epitope, deleting the sequence encoding the C terminal region. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted upstream of the modified exon 65. Western blot analysis confirmed accumulation of the truncated protein within neurons. (J:220151)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Reln Mutation:  124 strains or lines available
References
Original:  J:220151 Kohno T, et al., Importance of reelin C-terminal region in the development and maintenance of the postnatal cerebral cortex and its regulation by specific proteolysis. J Neurosci. 2015 Mar 18;35(11):4776-87
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/31/2018
MGI 6.12
The Jackson Laboratory