Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Fzd4tm1Nat
Name:	frizzled class receptor 4; targeted mutation 1, Jeremy Nathans
MGI ID:	MGI:2387667
Synonyms:	fz4(-), Fz4lacZ
Gene:	Fzd4  Location: Chr7:89053574-89062341 bp, + strand  Genetic Position: Chr7, 49.32 cM
Alliance:	Fzd4tm1Nat page

Germline Transmission:	Earliest citation of germline transmission: J:70078
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A cassette containing lacZ and neo was inserted at the start codon of the endogenous locus via homologous recombination. The inserted sequences replaced all but the last 70 bp of the protein coding region. Expression of beta-galactosidase was visualized by X-gal staining. (J:70078)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	15 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fzd4 Mutation:	29 strains or lines available

Original:	J:70078 Wang Y, et al., Progressive cerebellar, auditory, and esophageal dysfunction caused by targeted disruption of the frizzled-4 gene. J Neurosci. 2001 Jul 1;21(13):4761-71
All:	18 reference(s)