Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Irf7M2Btlr
Name:	interferon regulatory factor 7; mutation 2, Bruce Beutler
MGI ID:	MGI:5615723
Synonyms:	Houstonian
Gene:	Irf7  Location: Chr7:140843096-140846412 bp, - strand  Genetic Position: Chr7, 86.57 cM, cytoband F5
Alliance:	Irf7M2Btlr page

Strain of Origin:	C57BL/6J
Project Collection:	Beutler Mutagenetix

Allele Type:    Chemically induced (ENU) (Not Specified) Mutation:    Single point mutation   Mutation details: ENU mutagensis induced an A to G transition at base pair 141,264,022 (v38) on chromosome 7, or base pair 2,478 in the GenBank genomic region NC_000073. The mutation corresponds to residue 1,179 in the mRNA sequence NM_016850 within exon 8 of 10 total exons. The mutation results in a threonine (T) to alanine (A) substitution at position 246 (T246A). (J:217798) Inheritance:    Semidominant

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Irf7 Mutation:	23 strains or lines available

Original:	J:217798 Dao D, et al., Mutagenetix entry for Houstonian. MGI Direct Data Submission. 2015;
All:	1 reference(s)