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Sox2tm1.1Knd
Targeted Allele Detail
Nomenclature
Symbol: Sox2tm1.1Knd
Name: SRY (sex determining region Y)-box 2; targeted mutation 1.1, Hisato Kondoh
MGI ID: MGI:5613017
Synonyms: deltaN1, Sox2deltaN1
Gene: Sox2  Location: Chr3:34650405-34652461 bp, + strand  Genetic Position: Chr3, 16.93 cM, cytoband A2-B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:217059
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Hypomorph, Modified regulatory region, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsBy sequential targeting an IRES-EGFP and FRT flanked neo cassette were inserted downstream of the open reading frame. Flp mediated recombination removed the neo cassette. Then a loxP site and neo cassette and loxP site were inserted around the N1 enhancer element. Cre mediated recombination removed the N1 enhancer and neo cassette. Homozygous mice show loss of Sox2 expression in the zone at the caudal end of neural plate but expression is seen in the neural tube. (J:217059)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 10 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sox2 Mutation:  23 strains or lines available
References
Original:  J:217059 Takemoto T, et al., Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells. Nature. 2011 Feb 17;470(7334):394-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/10/2020
MGI 6.16
The Jackson Laboratory