Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tbx21tm1.1(flpe/ERT2)Gmld
Name:	T-box 21; targeted mutation 1.1, Graham M Lord
MGI ID:	MGI:5575639
Synonyms:	T-betfl
Gene:	Tbx21  Location: Chr11:96988897-97006157 bp, - strand  Genetic Position: Chr11, 60.95 cM, cytoband D
Alliance:	Tbx21tm1.1(flpe/ERT2)Gmld page

Germline Transmission:	Earliest citation of germline transmission: J:207104
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Conditional ready, Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Tbx21tm1.1(flpe/ERT2)Gmld expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Tbx21 (MGI:1888984)   Mutation details: A loxP site was inserted upstream of exon 4. An IRES, flpeERT2, polyadenylation sequence, FRT-flanked neomycin resistance cassette and a loxP site were inserted downstream of exon 6. Flp-mediated recombination removed the selection cassette and left exons 4 through 6 floxed. (J:207104)

Activity:	Tissue activity of this recombinase allele
Driver:	Tbx21 (mouse) Summary of all recombinase alleles driven by Tbx21. Alliance mouse Tbx21 gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbx21 Mutation:	36 strains or lines available

Original:	J:207104 Gokmen MR, et al., Genome-wide regulatory analysis reveals that T-bet controls Th17 lineage differentiation through direct suppression of IRF4. J Immunol. 2013 Dec 15;191(12):5925-32
All:	1 reference(s)