Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Fusem1Rkuhn
Name:	fused in sarcoma; endonuclease-mediated mutation 1, Ralf Kuhn
MGI ID:	MGI:5551889
Synonyms:	FusR513G
Gene:	Fus  Location: Chr7:127565276-127581204 bp, + strand  Genetic Position: Chr7, 69.87 cM
Alliance:	Fusem1Rkuhn page

Strain of Origin:

(FVB/N x D2B6F1)F1

Allele Type:    Endonuclease-mediated Mutation:    Nucleotide substitutions   Mutation details: TALEN targeting of exon 15 for homologous recombination with a synthetic oligodeoxynucleotide induced a point mutation (C to G) that results in the amino acid substitution of glycine for arginine at position 513 (R513G). Founder F29 contains the intended point mutation and an additional G to A nucleotide substituion within the TALEN-Fus15B targeting sequence. (J:201579)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fus Mutation:	39 strains or lines available

Original:	J:201579 Panda SK, et al., Highly efficient targeted mutagenesis in mice using TALENs. Genetics. 2013 Nov;195(3):703-13
All:	1 reference(s)