Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sox10tm1.1Sout
Name:	SRY (sex determining region Y)-box 10; targeted mutation 1.1, E Southard-Smith
MGI ID:	MGI:5544794
Synonyms:	Sox10tm1.1Vlcg
Gene:	Sox10  Location: Chr15:79039113-79048690 bp, - strand  Genetic Position: Chr15, 37.7 cM
Alliance:	Sox10tm1.1Sout page

Germline Transmission:	Earliest citation of germline transmission: J:200671
Parent Cell Line:	JM8.F6 (ES Cell)
Strain of Origin:	C57BL/6N

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A conditional by inversion (COIN) intron consisting of a lox66_SA-Egpf-polyA_lox71 was inserted in the antisense orientation into intron 3 via homologous recombination, splitting intron 3 into 2 new exons (94 and 2,258 bp in length). The two lox sites are in reverse complementation orientation, thus cre-mediated recombination will irreversibly invert the inserted sequence. In addition, an FRT flanked drug selection cassette (hygromycin- or neomycin-delta-thymidine kinase cassette was inserted after the COIN intron. Flp-mediated recombination removed the drug selection cassette. (J:200671)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sox10 Mutation:	33 strains or lines available

Original:	J:200671 Economides AN, et al., Conditionals by inversion provide a universal method for the generation of conditional alleles. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3179-88
All:	1 reference(s)