Foxa1tm1(cre)Sew
Targeted Allele Detail
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Symbol: |
Foxa1tm1(cre)Sew |
Name: |
forkhead box A1; targeted mutation 1, Susan E Waltz |
MGI ID: |
MGI:2386437 |
Gene: |
Foxa1 Location: Chr12:57587414-57593702 bp, - strand Genetic Position: Chr12, 24.7 cM
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Alliance: |
Foxa1tm1(cre)Sew page
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Germline Transmission: |
Earliest citation of germline transmission:
J:75503
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Parent Cell Line: |
E14.1 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Recombinase) |
Mutations: |
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Insertion, Intragenic deletion
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Foxa1tm1(cre)Sew expression driven by
1 gene
Knock-in expression driven by:
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Mutation details: The majority of exon 2 was replaced with a cassette containing NLS-cre. While the endogenous promoter is active from E8-8.5 through adulthood in endoderm derived tissues, namely, the lung, liver, and gastrointestinal tract, the expression of the targeted allele was ubiquitous.
(J:75503)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Foxa1
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Foxa1 Mutation: |
20 strains or lines available
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Original: |
J:75503 Waltz SE, et al., Ron-mediated cytoplasmic signaling is dispensable for viability but is required to limit inflammatory responses. J Clin Invest. 2001 Aug;108(4):567-76 |
All: |
2 reference(s) |
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