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Targeted Allele Detail
Symbol: Nkx6-1tm1.2Msan
Name: NK6 homeobox 1; targeted mutation 1.2, Maike Sander
MGI ID: MGI:5501147
Synonyms: Nkx6.1deltaf
Gene: Nkx6-1  Location: Chr5:101659184-101664711 bp, - strand  Genetic Position: Chr5, 48.84 cM
The gross morphology of Nkx6-1tm1Jlr/Nkx6-1tm1.2Msan embryos at E18.5

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:195153
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance (neo) cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neo cassette and left exon 2 floxed. Cre-mediated recombination removed exon 2. (J:195153)
Generation of the Nkx6-1tm1.1Msan and Nkx6-1tm1.2Msan alleles
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nkx6-1 Mutation:  2 strains or lines available
Original:  J:195153 Schaffer AE, et al., Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity. PLoS Genet. 2013 Jan;9(1):e1003274
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory