All Phenotypes Nkx6-1<tm1.2Msan> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nkx6-1^tm1.2Msan
targeted mutation 1.2, Maike Sander
MGI:5501147

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Nkx6-1^tm1Jlr/Nkx6-1^tm1.2Msan	involves: 129S6/SvEvTac * C57BL * DBA * SJL	MGI:5501190

Allelic Composition	Nkx6-1^tm1Jlr/Nkx6-1^tm1.2Msan
Genetic Background	involves: 129S6/SvEvTac * C57BL * DBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx6-1^tm1.2Msan mutation (0 available); any Nkx6-1 mutation (4 available)
Nkx6-1^tm1Jlr mutation (0 available); any Nkx6-1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

The gross morphology of Nkx6-1^tm1Jlr/Nkx6-1^tm1.2Msan embryos at E18.5

mortality/aging

neonatal lethality, complete penetrance ( J:195153 )

• mice die immediately after birth due to asphyxia

endocrine/exocrine glands

decreased pancreatic beta cell number ( J:195153 )

• at E18.5

behavior/neurological

forelimb paralysis ( J:195153 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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