Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Has2tm1Jam Name: hyaluronan synthase 2; targeted mutation 1, John A McDonald MGI ID: MGI:2386077 Synonyms: Has2- Gene: Has2  Location: Chr15:56529023-56557935 bp, - strand  Genetic Position: Chr15, 23.31 cM Alliance: Has2tm1Jam page

Growth retardation and yolk sac and somite abnormalities in Has2tm1Jam/Has2tm1Jam embryos Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:63748
Parent Cell Line:	GK129 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of the end of intron 3 and the first 60 codons of the cytoplasmic catalytic domain containing exon 4 with a PGK-neo cassette via homologous recombination. Homozygous mutant embryos were observed at days E9.5-E11.5 and RT-PCR analysis of embryonic mRNA detected truncated mutant transcripts. (J:63748)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

13 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Has2 Mutation:	35 strains or lines available

Original:	J:63748 Camenisch TD, et al., Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme [see comments]. J Clin Invest. 2000 Aug;106(3):349-60
All:	4 reference(s)