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| Caption | Abnormalities exhibited by Has2tm1Jam/Has2tm1Jam embryos. A: Yolk sac of an Has2tm1Jam/Has2+ (+/-) embryo. B: Yold sac from an Has2tm1Jam/Has2tm1Jam (-/-) littermate. Cross-sections of the yolk sac stained with hematoxylin and eosin are show in the inset. Note the presence of vitelline vessels (VV) containing nucleated red blood cells in the yolk sac of the heterozygous embryo. The endoderm and mesoderm are not fused in the homozygous embryo, and the red blood cells are free within this space. C and D: Representative wild type and mutant embryos at E9.5. Note the diminished size, the bloodless heart, and distorted somites of the mutant embryo. E and F: E9.5 wild type and mutant embryos stained for the endothelial marker PECAM. Note the absence of an organized vascular network expressing PECAM in the mutant embryo. P, pericardium; E, endoderm; M, mesoderm; OpP, optic placode; OtP, otic placode; first and second pharyngeal pouches are numbered. Scale bars in C-F, 500um. | ||||
| Copyright | This image is from Camenisch TD, J Clin Invest 2000 Aug;106(3):349-60 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:63748 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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