Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm13(CAG-MYC,-CD2*)Rsky
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 13, Klaus Rajewsky
MGI ID:	MGI:5444670
Synonyms:	MYCstopFL, R26StopFLMYC
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm13(CAG-MYC,-CD2*)Rsky page

Germline Transmission:	Earliest citation of germline transmission: J:188564
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Gt(ROSA)26Sortm13(CAG-MYC,-CD2*)Rsky expresses 2 genes Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human CD2 (914) Cd2  (MGI:88320) human MYC (4609) Bmyc  (MGI:88184) Myc  (MGI:97250)   Mutation details: A splice acceptor site, CAG promoter, floxed neo stop cassette human MYC cDNA, and an FRT flanked IRES sequence and human CD2 cDNA were knocked into intron 1 via homologous recombination. The human CD2 cDNA is a signaling-deficient truncated version. (J:188564)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:188564 Calado DP, et al., The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers. Nat Immunol. 2012 Nov;13(11):1092-100
All:	17 reference(s)