Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tyrc-Wtsi
Name:	tyrosinase; albino Wellcome Trust Sanger Institute
MGI ID:	MGI:5442732
Gene:	Tyr  Location: Chr7:87073979-87142637 bp, - strand  Genetic Position: Chr7, 49.01 cM
Alliance:	Tyrc-Wtsi page

Mutant Cell Line:	EPD0176_3_A10
Germline Transmission:	Earliest citation of germline transmission: J:188986
Parent Cell Line:	JM8.N4 (ES Cell)
Strain of Origin:	C57BL/6N

Allele Type:    Spontaneous Mutation:    Intragenic deletion     Vector: L1L2_Bact_P   Mutation details: The mutation is a 14.3 kb deletion of the tyrosinase gene spanning from 940 bp 5' of exon 1 (including the minimal promoter region) to 3.75 kb 3' of exon 2. This mutation arose spontaneously in EUCOMM embryonic stem (ES) cell clone EPD0176_3_A10, which was produced from JM8.N4 embryonic stem (ES) cells. (J:188986) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tyr Mutation:	375 strains or lines available

Original:	J:188986 Ryder E, et al., An albino C57BL/6N mouse strain. MGI Direct Data Submission. 2012;
All:	2 reference(s)