Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | Notes | References

Symbol:	Col1a1tm1(tetO-YAP1*)Fcam
Name:	collagen, type I, alpha 1; targeted mutation 1, Fernando D Camargo
MGI ID:	MGI:5316453
Synonyms:	TetO-YAP1, Yap1-S127A
Gene:	Col1a1  Location: Chr11:94827050-94843868 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D
Alliance:	Col1a1tm1(tetO-YAP1*)Fcam page

Germline Transmission:	Earliest citation of germline transmission: J:141457
Parent Cell Line:	KH2 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Humanized sequence, Inducible, Inserted expressed sequence, RMCE-ready) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Col1a1tm1(tetO-YAP1*)Fcam expresses 1 gene Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human YAP1 (10413) Yap1  (MGI:103262)   Mutation details: RMCE on KH2 cells inserted a cassette, which contained a tetracycline response element driving doxycycline-inducible expression of the human cDNA with nucleotide substitutions that result in the amino acid substitution of alanine for serine at position 127 (S127A), into the 3'UTR. This mutation produces a protein with increased nuclear localization and transcriptional activity compared with the wild-type protein. (J:141457)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:	160 strains or lines available

Original:	J:141457 Camargo FD, et al., YAP1 increases organ size and expands undifferentiated progenitor cells. Curr Biol. 2007 Dec 4;17(23):2054-60
All:	36 reference(s)