Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Fzd4tm1Lex
Name:	frizzled class receptor 4; targeted mutation 1, Lexicon Genetics
MGI ID:	MGI:5312685
Gene:	Fzd4  Location: Chr7:89053574-89062341 bp, + strand  Genetic Position: Chr7, 49.32 cM
Alliance:	Fzd4tm1Lex page

Germline Transmission:	Earliest citation of germline transmission: J:181399
Parent Cell Line:	Lex-1 (ES Cell)
Strain of Origin:	129S5/SvEvBrd
Project Collection:	Lexicon

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. (J:181399)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fzd4 Mutation:	29 strains or lines available

Original:	J:181399 Paes KT, et al., Frizzled 4 is required for retinal angiogenesis and maintenance of the blood-retina barrier. Invest Ophthalmol Vis Sci. 2011 Aug;52(9):6452-61
All:	1 reference(s)