Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Agttm1.1Itl
Name:	angiotensinogen; targeted mutation 1.1, inGenious Targeting Laboratory
MGI ID:	MGI:5305952
Synonyms:	Agtfl
Gene:	Agt  Location: Chr8:125283326-125296445 bp, - strand  Genetic Position: Chr8, 72.81 cM
Alliance:	Agttm1.1Itl page

Germline Transmission:	Earliest citation of germline transmission: J:178836
Parent Cell Line:	iTL IC1 (ES Cell)
Strain of Origin:	C57BL/6NTac

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 2 and an FRT and loxP flanked neo cassette were inserted downstream of exon 2 via homologous recombination. Flp mediated recombination deleted the neo cassette leaving exon 2 floxed. (J:178836)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Agt Mutation:	33 strains or lines available

Original:	J:178836 Yiannikouris F, et al., Adipocyte-specific deficiency of angiotensinogen decreases plasma angiotensinogen concentration and systolic blood pressure in mice. Am J Physiol Regul Integr Comp Physiol. 2012 Jan 15;302(2):R244-51
All:	10 reference(s)