Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nkx2-2tm3Suss
Name:	NK2 homeobox 2; targeted mutation 3, Lori Sussel
MGI ID:	MGI:5302422
Synonyms:	Nkx2.2LacZ
Gene:	Nkx2-2  Location: Chr2:147019466-147036163 bp, - strand  Genetic Position: Chr2, 72.63 cM, cytoband H
Alliance:	Nkx2-2tm3Suss page

Germline Transmission:	Earliest citation of germline transmission: J:178173
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout, RMCE-ready, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Recombination mediated cassette exchange (RMCE) into Nkx2-2tm1Suss inserted a full length lacZ gene with a nuclear localization signal in place of the existing cassette. Exons 1 and 2 were deleted in the original allele. LacZ expression recapitulates endogenous gene expression. (J:178173, J:187468)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nkx2-2 Mutation:	14 strains or lines available

Original:	J:178173 Mastracci TL, et al., Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression. Dev Biol. 2011 Nov 1;359(1):1-11
All:	5 reference(s)