Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Leprtm5Mgmj
Name:	leptin receptor; targeted mutation 5, Martin G Myers, Jr
MGI ID:	MGI:5301119
Synonyms:	leprF1077
Gene:	Lepr  Location: Chr4:101574601-101672549 bp, + strand  Genetic Position: Chr4, 46.96 cM
Alliance:	Leprtm5Mgmj page

Germline Transmission:	Earliest citation of germline transmission: J:179119
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted Mutations:    Insertion, Single point mutation   Mutation details: The targeting vector contained a nucleotide substitution that results in the amino acid substitution of phenyalanine for tyrosine at position 1077 (Y1077F) and a floxed NEO cassette. This mutation is predicted to abolish STAT5 activation by the mutated protein. (J:179119)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lepr Mutation:	121 strains or lines available

Original:	J:179119 Myers MG, Direct Data Submission 2012/01/11. MGI Direct Data Submission. 2012;
All:	2 reference(s)