Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mapttm1(Setdb1)Akba
Name:	microtubule-associated protein tau; targeted mutation 1, Schahram Akbarian
MGI ID:	MGI:5298877
Synonyms:	tauSetdb1
Gene:	Mapt  Location: Chr11:104122216-104222916 bp, + strand  Genetic Position: Chr11, 67.79 cM, cytoband E1
Alliance:	Mapttm1(Setdb1)Akba page

Germline Transmission:	Earliest citation of germline transmission: J:178512
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted Mutation:    Insertion   Mutation details: The myc-tagged mouse cDNA and a neo cassette were inserted downstream of the start codon in exon 2. Western blot analysis confirmed protein expression in the cerebral cortex, striatum, hippocampus, cerebellum, thalamus, hypothalamus, peri-aqueductal gray, and substantia nigra. (J:178512)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mapt Mutation:	428 strains or lines available

Original:	J:178512 Jiang Y, et al., Setdb1-mediated histone H3K9 hypermethylation in neurons worsens the neurological phenotype of Mecp2-deficient mice. Neuropharmacology. 2011 Jun;60(7-8):1088-97
All:	1 reference(s)