Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Trp63tm3.1Brd
Name:	transformation related protein 63; targeted mutation 3.1, Allan Bradley
MGI ID:	MGI:2385473
Synonyms:	p63flox
Gene:	Trp63  Location: Chr16:25502513-25710838 bp, + strand  Genetic Position: Chr16, 17.37 cM
Alliance:	Trp63tm3.1Brd page

Germline Transmission:	Earliest citation of germline transmission: J:75125
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: The ubiquitous expression of cre recombinase resulted in the excision of the neo cassette from Trp63tm3Brd. Exons 5 through 7, encoding the DNA-binding domain, were left flanked by single loxP sites in introns 4 and 7. (J:75125)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp63 Mutation:	60 strains or lines available

Original:	J:75125 Mills AA, et al., Conditional inactivation of p63 by Cre-mediated excision. Genesis. 2002 Feb;32(2):138-41
All:	20 reference(s)