Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm3.1Brd mutation
(0 available);
any
Trp63 mutation
(60 available)
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cellular
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• when keratinocytes are treated with an adenovirus cre, cellular proliferation is decreased
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• when keratinocytes are treated with an adenovirus cre, cells exhibit premature senescence
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT5-cre/PGR)1Der mutation
(0 available)
Trp63tm2Brd mutation
(1 available);
any
Trp63 mutation
(60 available)
Trp63tm3.1Brd mutation
(0 available);
any
Trp63 mutation
(60 available)
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cellular
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• following treatment with mifepristonein in utero, mice exhibit an increase in cellular senescence
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craniofacial
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• at E17.5 following treatment with mifepristonein in utero
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limbs/digits/tail
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• at E17.5 following treatment with mifepristonein in utero
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growth/size/body
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• following treatment with mifepristonein at 8 months of age
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skeleton
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• following treatment with mifepristonein at 8 months of age, mice exhibit lordokyphosis that increases with severity as mice age
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integument
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• following treatment with mifepristonein at 8 months of age, mice exhibit severe alopecia
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• at E17.5 following treatment with mifepristonein in utero or at 8 months of age
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• following treatment with mifepristonein utero, mice exhibit stratified epidermal layer and arrested epidermal morphogenesis
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