Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Arg1tm1Pmu
Name:	arginase, liver; targeted mutation 1, Peter J Murray
MGI ID:	MGI:3826847
Synonyms:	Arg1flox, Argfl
Gene:	Arg1  Location: Chr10:24791105-24803368 bp, - strand  Genetic Position: Chr10, 12.26 cM
Alliance:	Arg1tm1Pmu page

Germline Transmission:	Earliest citation of germline transmission: J:143229
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 7 and a loxP-flanked neomycin selection cassette was inserted downstream of exon 8. Transient expression of cre recombinase removed the neomycin cassette, leaving exons 7 and 8 floxed. These exons encode in addition to the oligomerization domain, two highly conserved aspartic acid residues that are essential to the enzymatic activity of the gene product. Correct targeting was confirmed by genomic PCR. (J:143229)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Arg1 Mutation:	25 strains or lines available

Original:	J:143229 El Kasmi KC, et al., Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens. Nat Immunol. 2008 Dec;9(12):1399-406
All:	51 reference(s)