Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rr117tm1.1Dje
Name:	regulatory region 117; targeted mutation 1.1, Douglas J Epstein
MGI ID:	MGI:4948508
Synonyms:	ShhdeltaSBE1, Shhtm1.1Dje
Gene:	Rr117  Location: unknown  Genetic Position: Chr5, Syntenic
Alliance:	Rr117tm1.1Dje page

Germline Transmission:	Earliest citation of germline transmission: J:170540
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Modified regulatory region) Mutations:    Insertion, Intragenic deletion   Rr117tm1.1Dje involves 1 genes/genome features (Shh) View all   Mutation details: A loxP site was inserted upstream of the 525 bp Shh brain enhancer 1 (SBE1) in intron 2. In addition, an FRT site flanked neomycin resistance gene cassette and a second loxP site were inserted immediately downstream of SBE1. Subsequent cre expression excised both SBE1 and the neo cassette. (J:170540)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rr117 Mutation:	0 strains or lines available

Original:	J:170540 Jeong Y, et al., Spatial and temporal requirements for sonic hedgehog in the regulation of thalamic interneuron identity. Development. 2011 Feb;138(3):531-41
All:	1 reference(s)