Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fasltm1.1Cgm
Name:	Fas ligand; targeted mutation 1.1, Geert Michel
MGI ID:	MGI:4888490
Synonyms:	FasL deltaIntra
Gene:	Fasl  Location: Chr1:161608260-161616064 bp, - strand  Genetic Position: Chr1, 69.95 cM
Alliance:	Fasltm1.1Cgm page

Germline Transmission:	Earliest citation of germline transmission: J:168406
Parent Cell Line:	TBV2 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Not Applicable) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1 was replaced with one in which the sequence corresponding to the intracellular domain (amino acids 2 through 78) was removed. A floxed neo cassette used for selection was removed by cre-mediated recombination. (J:168406)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fasl Mutation:	36 strains or lines available

Original:	J:168406 Luckerath K, et al., Immune modulation by Fas ligand reverse signaling: lymphocyte proliferation is attenuated by the intracellular Fas ligand domain. Blood. 2011 Jan 13;117(2):519-29
All:	1 reference(s)