Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bdnftm1Meg
Name:	brain derived neurotrophic factor; targeted mutation 1, Micheal E Greenberg
MGI ID:	MGI:3809491
Synonyms:	BdnfIV-
Gene:	Bdnf  Location: Chr2:109505045-109557352 bp, + strand  Genetic Position: Chr2, 56.63 cM
Alliance:	Bdnftm1Meg page

Germline Transmission:	Earliest citation of germline transmission: J:139381
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted Mutation:    Intragenic deletion   Mutation details: The non-coding exon IV plus some promoter sequence was deleted from nucleotides -160 to +281 relative to the transcription initiation start site. Basal synthesis of the gene product was unaffected but translation of the gene in neurons did not increase in response to Ca2+ influx. (J:139381)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bdnf Mutation:	41 strains or lines available

Original:	J:139381 Singh KK, et al., Developmental axon pruning mediated by BDNF-p75NTR-dependent axon degeneration. Nat Neurosci. 2008 Jun;11(6):649-58
All:	1 reference(s)