Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tal1tm1(tTA)Bock
Name:	T cell acute lymphocytic leukemia 1; targeted mutation 1, Ernesto Bockamp
MGI ID:	MGI:3806344
Synonyms:	SCLtTA-2S, SCL-tTA-S2
Gene:	Tal1  Location: Chr4:114913623-114928952 bp, + strand  Genetic Position: Chr4, 52.73 cM
Alliance:	Tal1tm1(tTA)Bock page

Germline Transmission:	Earliest citation of germline transmission: J:138070
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Transactivator) Mutations:    Insertion, Nucleotide substitutions   Mutation details: All ATG codons in exon 4 and the first in exon 4 were modified to GGG codons to prevent translation initiation. A floxed neo cassette and the tTA-2S transactivator were inserted into exon 5. Germ line, cre-mdiated recombination was used to remove the neo cassette. (J:138070)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tal1 Mutation:	33 strains or lines available

Original:	J:138070 Bockamp E, et al., Tetracycline-controlled transgenic targeting from the SCL locus directs conditional expression to erythrocytes, megakaryocytes, granulocytes, and c-kit-expressing lineage-negative hematopoietic cells. Blood. 2006 Sep 1;108(5):1533-41
All:	6 reference(s)