Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Atp7aMo-2Btlr Name: ATPase, Cu++ transporting, alpha polypeptide; mottled 2 Bruce Beutler MGI ID: MGI:3806010 Synonyms: Atp7aTigrou, Tigrou Gene: Atp7a  Location: ChrX:105070882-105168532 bp, + strand  Genetic Position: ChrX, 47.36 cM Alliance: Atp7aMo-2Btlr page

Coat color phenotypes of mutants carrying the Atp7aMo-Btlr, Atp7aMo-2Btlr, or Atp7aMo-3Btlr allele Show the 1 phenotype image(s) involving this allele.

Strain of Origin:	C57BL/6J
Project Collection:	Beutler Mutagenetix

Allele Type:    Chemically induced (ENU) Mutation:    Single point mutation   Mutation details: The Tigrou mutation, discovered in a G1 daughter of an ENU-mutagenized male mouse, corresponds to a G-to-T transversion at nucleotide position 1485 of the gene, in the fifth of 23 total exons. It results in replacement of the glutamic acid codon at position 469 by a stop codon (E469Ter), which would truncate the protein before the fifth metal binding domain. It is unknown whether this truncated protein is expressed in mutant mice. (J:138687, J:188598) Inheritance:    Semidominant

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atp7a Mutation:	69 strains or lines available

Original:	J:138687 Du X, et al., Record for "Tigrou" updated 2nd of June, 2008. MGI Direct Data Submission. 2008;
All:	2 reference(s)