Summary | Transgene origin | Transgene description | Expression | Recombinase activity | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Speer6-ps1Tg(Alb-cre)21Mgn
Name:	spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1; transgene insertion 21, Mark A Magnuson
MGI ID:	MGI:2176228
Synonyms:	Albcre, Alb-cre, AlbCre, Alb-Cre, Albcre2, albumin-cre, crAlb, CreALB, Tg(Alb-cre)21Mg
Gene:	Speer6-ps1  Location: Chr13:3236206-3239317 bp, + strand  Genetic Position: Chr13, 1.78 cM
Alliance:	Speer6-ps1Tg(Alb-cre)21Mgn page

Strain of Origin:

(C57BL/6 x DBA)F2

Transgene Type:    Transgenic (Recombinase) Mutations:    Insertion, Intragenic deletion   Speer6-ps1Tg(Alb-cre)21Mgn expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Alb (MGI:87991)   Mutation details: The transgene contains a 2.34 kb mouse albumin enhancer/promoter (M. Magnuson verified mouse promoter, personal communication), a nuclear localization sequence-modified Cre recombinase gene and a 2.1 kb fragment from the human growth hormone gene. The promoter is active in hepatocyte cells of the liver. 7 copies of the transgene are estimated to be present. Line 21 inserted into the gene at 3172116-3172120 (Build GRCm38/mm10) resulting in a 4 bp deletion. Founder line x has a copy number of approximately 10. (J:51826)

Activity:	Tissue activity of this recombinase allele
Driver:	Alb (mouse) Summary of all recombinase alleles driven by Alb. Comparative matrix view of recombinase activities Alliance mouse Alb gene page

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

156467 assay results 86 RNA-Seq or microarray experiment(s)

List all tumor models in MMHCdb carrying Speer6-ps1Tg(Alb-cre)21Mgn

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Speer6-ps1 Mutation:	4 strains or lines available

Original:	J:51826 Postic C, et al., Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem. 1999 Jan 1;274(1):305-15
All:	1455 reference(s)