Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fasldel1Hong
Name:	Fas ligand; deletion 1, Wanjin Hong
MGI ID:	MGI:3803664
Synonyms:	FasLdel
Gene:	Fasl  Location: Chr1:161608260-161616064 bp, - strand  Genetic Position: Chr1, 69.95 cM
Alliance:	Fasldel1Hong page

Strain of Origin:

Not Specified

Allele Type:    Spontaneous Mutation:    Intragenic deletion   Mutation details: A spontaneous mutation results in the small deletion of 5 nucleotides at the 5' end of the first intron, removing the invariant GT dinucleotide in the 5' splice consensus sequence. Splicing between the first and second exons is aberrant, generating non-functional polypeptides and creating a loss-of-function allele. (J:112563) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fasl Mutation:	36 strains or lines available

Original:	J:112563 Wang CC, et al., Mouse lymphomas caused by an intron-splicing donor site deletion of the FasL gene. Biochem Biophys Res Commun. 2006 Oct 13;349(1):50-8
All:	1 reference(s)