Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Col1a1tm6(tetO-MSI2)Jae
Name:	collagen, type I, alpha 1; targeted mutation 6, Rudolf Jaenisch
MGI ID:	MGI:4822360
Synonyms:	Coll-TetO-MSI2
Gene:	Col1a1  Location: Chr11:94827050-94843868 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D
Alliance:	Col1a1tm6(tetO-MSI2)Jae page

Germline Transmission:	Earliest citation of germline transmission: J:163322
Parent Cell Line:	KH2 (ES Cell)
Strain of Origin:	(C57BL/6 x 129S4/SvJae)F1

Allele Type:    Targeted (Humanized sequence, Inducible, Inserted expressed sequence, RMCE-ready) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Col1a1tm6(tetO-MSI2)Jae expresses 1 gene Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human MSI2 (124540) Msi2  (MGI:1923876)   Mutation details: RMCE on KH2 cells inserted a cassette that contains a tetracycline operator and minimal CMV promoter drives inducible expression of the human cDNA preceded by a splice acceptor and polyadenylation sequence and followed by an FRT flanked PGK-neo cassette and promotorless hygro cassette into the 3'UTR. (J:163322)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:	160 strains or lines available

Original:	J:163322 Kharas MG, et al., Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia. Nat Med. 2010 Aug;16(8):903-8
All:	4 reference(s)