Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Icostm1Wks
Name:	inducible T cell co-stimulator; targeted mutation 1, Woong-Kyung Suh
MGI ID:	MGI:4415347
Gene:	Icos  Location: Chr1:61017086-61039479 bp, + strand  Genetic Position: Chr1, 30.6 cM
Alliance:	Icostm1Wks page

Germline Transmission:	Earliest citation of germline transmission: J:155586
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutations:    Insertion, Nucleotide substitutions   Mutation details: Tyrosine 181 in exon 3 was mutated to phenylalanine by a single A-T transversion. A diagnostic EcoRI site was also introduced into exon 3 as well as a floxed neo cassette. (J:155586)

Generation of the Icostm1Wks and Icostm1.1Wks alleles

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Icos Mutation:	35 strains or lines available

Original:	J:155586 Gigoux M, et al., Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20371-6
All:	1 reference(s)